{"id":21,"date":"2015-02-02T20:09:46","date_gmt":"2015-02-02T20:09:46","guid":{"rendered":"http:\/\/faculty.eng.fau.edu\/kim\/?page_id=21"},"modified":"2018-08-29T15:31:21","modified_gmt":"2018-08-29T15:31:21","slug":"droplet-microfluidics","status":"publish","type":"page","link":"https:\/\/faculty.eng.fau.edu\/kim\/research\/droplet-microfluidics\/","title":{"rendered":"Droplet Microfluidics"},"content":{"rendered":"<h3>1. Aqueous-Two Phase System Droplet Generation<\/h3>\n<p>Recent advent of Aqueous-Two-Phase-System (ATPS), more biologically friendly compared to conventional oil-water systems, has shown great potential to rapidly generate aqueous droplets without tedious post-processing. However, understanding of the underlying physics of droplet formation in ATPS is still in its infancy. We are aiming to generate aqueous droplets in the aqueous phase at high frequency of generation with much smaller size when compared with the conventional methods.<\/p>\n<p><a href=\"http:\/\/faculty.eng.fau.edu\/kim\/files\/2018\/08\/1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-422\" src=\"http:\/\/faculty.eng.fau.edu\/kim\/files\/2018\/08\/1-300x211.png\" alt=\"\" width=\"300\" height=\"211\" srcset=\"https:\/\/faculty.eng.fau.edu\/kim\/files\/2018\/08\/1-300x211.png 300w, https:\/\/faculty.eng.fau.edu\/kim\/files\/2018\/08\/1-768x541.png 768w, https:\/\/faculty.eng.fau.edu\/kim\/files\/2018\/08\/1-1024x721.png 1024w, https:\/\/faculty.eng.fau.edu\/kim\/files\/2018\/08\/1-624x440.png 624w, https:\/\/faculty.eng.fau.edu\/kim\/files\/2018\/08\/1.png 1597w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a>\u00a0\u00a0<a href=\"http:\/\/faculty.eng.fau.edu\/kim\/files\/2018\/08\/Fig-for-homepage.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-425\" src=\"http:\/\/faculty.eng.fau.edu\/kim\/files\/2018\/08\/Fig-for-homepage-300x254.png\" alt=\"\" width=\"300\" height=\"254\" srcset=\"https:\/\/faculty.eng.fau.edu\/kim\/files\/2018\/08\/Fig-for-homepage-300x254.png 300w, https:\/\/faculty.eng.fau.edu\/kim\/files\/2018\/08\/Fig-for-homepage-624x529.png 624w, https:\/\/faculty.eng.fau.edu\/kim\/files\/2018\/08\/Fig-for-homepage.png 689w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<div class=\"su-youtube su-u-responsive-media-yes\"><iframe loading=\"lazy\" width=\"600\" height=\"400\" src=\"https:\/\/www.youtube.com\/embed\/nt09qa7anvg?\" frameborder=\"0\" allowfullscreen allow=\"autoplay; encrypted-media; picture-in-picture\" title=\"\"><\/iframe><\/div>\n<div class=\"su-youtube su-u-responsive-media-yes\"><iframe loading=\"lazy\" width=\"600\" height=\"400\" src=\"https:\/\/www.youtube.com\/embed\/Tz13PjI4F0k?\" frameborder=\"0\" allowfullscreen allow=\"autoplay; encrypted-media; picture-in-picture\" title=\"\"><\/iframe><\/div>\n<p>&nbsp;<\/p>\n<h3>2. High Inertial Droplet Microfluidics<\/h3>\n<p>Droplet-based microfluidics have become ubiquitous and of great importance for applications in biological and chemical fields including drug delivery.\u00a0 Unlike typical oil-liquid systems, we are here aiming at using gas-liquid scheme to make it possible to create digital droplet microfluidics systems in applications that require high inertial effects due to the presence of a gaseous phase.\u00a0 There are two main research thrusts in droplet microfluidics research:<\/p>\n<p>&nbsp;<\/p>\n<p><strong>1) Droplet generation at T-junction or flow focusing geometries<\/strong><\/p>\n<p>Using various microchannel geometries, several aspects of high inertial droplet flows such as geometry dependence, flow regime mapping, and interactions of forces (surface tension, viscous force, inertial forces, etc.) will be investigated.<\/p>\n<p>&nbsp;<\/p>\n<div style=\"text-align: center;line-height: 19px\"><a href=\"https:\/\/sites.google.com\/site\/myeongsubkim\/research\/Drop-Setup.png?attredirects=0\"><span style=\"color: #000000;font-size: small\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/sites.google.com\/site\/myeongsubkim\/_\/rsrc\/1400208634726\/research\/Drop-Setup.png?height=217&amp;width=400\" alt=\"\" width=\"400\" height=\"217\" border=\"0\" \/><\/span><\/a><\/div>\n<div style=\"text-align: center;line-height: 19px\"><span style=\"color: #000000;font-size: small\">&lt;Experimental Setup&gt;<\/span><\/div>\n<div style=\"text-align: left\">\n<div style=\"text-align: left;line-height: 19px\">\n<div style=\"text-align: center\">\n<div>\n<div><span style=\"color: #000000;font-size: small\">\u00a0<\/span><\/div>\n<\/div>\n<\/div>\n<div style=\"text-align: center\">\n<div>\n<div style=\"text-align: left\">\n<p>&nbsp;<\/p>\n<p><strong>&lt;Droplet Generation: dripping&gt;<\/strong><\/p>\n<div class=\"su-youtube su-u-responsive-media-yes\"><iframe loading=\"lazy\" width=\"600\" height=\"400\" src=\"https:\/\/www.youtube.com\/embed\/mQgnA2yAwI8?\" frameborder=\"0\" allowfullscreen allow=\"autoplay; encrypted-media; picture-in-picture\" title=\"\"><\/iframe><\/div>\n<\/div>\n<div style=\"text-align: left\">\n<p>&nbsp;<\/p>\n<p><strong>&lt;Droplet Generation: jetting&gt;<\/strong><\/p>\n<div class=\"su-youtube su-u-responsive-media-yes\"><iframe loading=\"lazy\" width=\"600\" height=\"400\" src=\"https:\/\/www.youtube.com\/embed\/KimN9VcaFmY?\" frameborder=\"0\" allowfullscreen allow=\"autoplay; encrypted-media; picture-in-picture\" title=\"\"><\/iframe><\/div>\n<\/div>\n<div style=\"text-align: left\"><\/div>\n<\/div>\n<\/div>\n<div style=\"text-align: left\">\n<div style=\"text-align: center\">\n<div>\n<div>\n<div>\n<p><span style=\"color: #000000;font-size: small\"><span style=\"color: #000000;font-size: small\"><span style=\"color: #ffffff\">a<\/span>\u00a0<\/span><\/span><\/p>\n<div><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><strong>2) High inertial droplet mixing by chaotic advection<\/strong><\/p>\n<p>High inertial droplet flows will also be employed to enhance micromixing by chaotic advection at high Reynolds number flows, compared to conventional oil-liquid systems.<\/p>\n<p>&nbsp;<\/p>\n<div style=\"text-align: center;line-height: 19px\"><span style=\"color: #000000;font-size: small\"><a href=\"https:\/\/sites.google.com\/site\/myeongsubkim\/research\/Drop-Mix1.png?attredirects=0\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/sites.google.com\/site\/myeongsubkim\/_\/rsrc\/1400208791344\/research\/Drop-Mix1.png?height=257&amp;width=400\" alt=\"\" width=\"400\" height=\"257\" border=\"0\" \/><\/a><\/span><\/div>\n<div style=\"text-align: center;line-height: 19px\">&lt;Schematic of Collision Droplet Mixing*&gt;<\/div>\n<p>&nbsp;<\/p>\n<div style=\"text-align: center;line-height: 19px\"><span style=\"color: #000000;font-size: small\"><a href=\"https:\/\/sites.google.com\/site\/myeongsubkim\/research\/Drop-Mix2.png?attredirects=0\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/sites.google.com\/site\/myeongsubkim\/_\/rsrc\/1400208814599\/research\/Drop-Mix2.png?height=143&amp;width=400\" alt=\"\" width=\"400\" height=\"143\" border=\"0\" \/><\/a><\/span><\/div>\n<div style=\"text-align: center;line-height: 19px\">&lt;Sequential Fluorescence Images of Droplet Collision*&gt;<\/div>\n<p>* Reference: B. Carroll, C. Hidrovo, Exp Fluid, 2012<\/p>\n<h3><\/h3>\n<h3><strong>3. Polymeric Bio-Particle Synthesis<\/strong><\/h3>\n<p>One of significant hindrances in sustained pulmonary drug delivery is low efficiency of drug absorption. \u00a0The major reason in this poor inhalation uptake is the fact that the drug size is too large to inhale. \u00a0The most appropriate aerodynamic size range for particles to be respirable is 0.5-5 um. The strategy for sustained controlled pulmonary drug delivery involves the engineering of dried delivery carrier systems that are able to provide respirable aerodynamic size, and offer stealth characteristics to hide themselves from macrophages in addition to showing desirable controlled releases kinetics. \u00a0This research will develop methodologies to make polymeric biodegradable particles at a scale of target aero diameter as a drug carrier system using microfluidics techniques.<\/p>\n<p><span style=\"color: #ffffff\">aaaaaaaaaaaaaaa<\/span><a href=\"https:\/\/sites.google.com\/site\/myeongsubkim\/research\/Gelation1.png?attredirects=0\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone\" src=\"https:\/\/sites.google.com\/site\/myeongsubkim\/_\/rsrc\/1400244795708\/research\/Gelation1.png?height=240&amp;width=320\" alt=\"\" width=\"320\" height=\"240\" border=\"0\" \/><\/a>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0&lt;Droplet Generation in Oil Phase&gt;<\/p>\n<p><span style=\"color: #ffffff\">aaaaaaaaaaaaaaa<\/span><a href=\"https:\/\/sites.google.com\/site\/myeongsubkim\/research\/Gelation2.png?attredirects=0\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/sites.google.com\/site\/myeongsubkim\/_\/rsrc\/1400244824261\/research\/Gelation2.png?height=236&amp;width=320\" alt=\"\" width=\"320\" height=\"236\" border=\"0\" \/><\/a>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0&lt;Droplet Generation in Gas Phase&gt;<\/p>\n<p>&nbsp;<\/p>\n<p><strong>&lt;Polymerization of calcium alginate in a bulk phase&gt;<\/strong><\/p>\n<div class=\"su-youtube su-u-responsive-media-yes\"><iframe loading=\"lazy\" width=\"600\" height=\"400\" src=\"https:\/\/www.youtube.com\/embed\/vYJcUHAOEI8?\" frameborder=\"0\" allowfullscreen allow=\"autoplay; encrypted-media; picture-in-picture\" title=\"\"><\/iframe><\/div>\n<p>&nbsp;<\/p>\n<p><strong>&lt;Generation of droplet family&gt;<\/strong><\/p>\n<div class=\"su-youtube su-u-responsive-media-yes\"><iframe loading=\"lazy\" width=\"600\" height=\"400\" src=\"https:\/\/www.youtube.com\/embed\/KVAry2gfT6Y?\" frameborder=\"0\" allowfullscreen allow=\"autoplay; encrypted-media; picture-in-picture\" title=\"\"><\/iframe><\/div>\n<div style=\"text-align: left;color: #000000;line-height: 19px;font-size: small\"><\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>1. Aqueous-Two Phase System Droplet Generation Recent advent of Aqueous-Two-Phase-System (ATPS), more biologically friendly compared to conventional oil-water systems, has shown great potential to rapidly generate aqueous droplets without tedious post-processing. However, understanding of the underlying physics of droplet formation in ATPS is still in its infancy. We are aiming to generate aqueous droplets in [&hellip;]<\/p>\n","protected":false},"author":74,"featured_media":0,"parent":2,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-21","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/faculty.eng.fau.edu\/kim\/wp-json\/wp\/v2\/pages\/21","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/faculty.eng.fau.edu\/kim\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/faculty.eng.fau.edu\/kim\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/faculty.eng.fau.edu\/kim\/wp-json\/wp\/v2\/users\/74"}],"replies":[{"embeddable":true,"href":"https:\/\/faculty.eng.fau.edu\/kim\/wp-json\/wp\/v2\/comments?post=21"}],"version-history":[{"count":25,"href":"https:\/\/faculty.eng.fau.edu\/kim\/wp-json\/wp\/v2\/pages\/21\/revisions"}],"predecessor-version":[{"id":437,"href":"https:\/\/faculty.eng.fau.edu\/kim\/wp-json\/wp\/v2\/pages\/21\/revisions\/437"}],"up":[{"embeddable":true,"href":"https:\/\/faculty.eng.fau.edu\/kim\/wp-json\/wp\/v2\/pages\/2"}],"wp:attachment":[{"href":"https:\/\/faculty.eng.fau.edu\/kim\/wp-json\/wp\/v2\/media?parent=21"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}